4/10
Overhyped
BS Scale Score
Promising but wildly exaggerated claims
"Ipamorelin is the cleanest growth hormone peptide with zero cortisol spike"
1-3
Mostly Real
4-6
Overhyped
7-10
Mostly BS
The Verdict
It is cleaner than GHRP-6. "Zero cortisol spike" is technically accurate at low doses — until it isn't.
The Evidence
Ipamorelin is a third-generation ghrelin mimetic, and the "clean" reputation is partially earned: unlike GHRP-6, it does not significantly spike cortisol or prolactin in standard doses. That makes it a genuinely interesting research peptide. The problem is "zero." In dose-escalation studies, cortisol suppression holds up — until doses go high. Biohacker protocols frequently exceed research doses because "more is better" is the default assumption. There are also no long-term human safety trials for ipamorelin. Short-term studies look fine. The compound has never been approved by any regulatory body for human use, which means the safety case is built on small studies and competitive-benchmarking against GHRP-6, not absolute safety data. Cleaner than alternatives is not the same as clean.
Vetted Clinicians
Ready to talk to a real doctor?
We've vetted clinicians who practice evidence-based peptide therapy and won't sell you a TikTok protocol.
Find a Vetted Clinician →Score Your Own Claim
Think you have a peptide claim that can't be debunked? Let's find out.
Try the Claim Scorer